Analisis Kadar Biomarker Urine Monocyte Chemoattractant Protein-1Terhadap Klasifikasi Histopatologi Nefritis Lupus

Jurnal ID
34
Tahun Jurnal
2013
Volume Jurnal
Volume IV
Pengarang
Yuliana Salman
Abstract

Systemiclupuserythematosus(SLE) is an autoimmune diseasecharacterizedbychronicandacuteinflammation. The common of serious complicationsinSLEislupusnephritis.. Biomarker that showed high specificity for SLE especially in lupus nephritis is Monocyte Chemoattractant Protein urine-1 (uMCP-1). In Indonesia, correlation between uMCP-1 with lupus nephritis still unknown. This approach is expected to replace renal biopsy in histopathological classification of lupus nephritis.This studyis anobservational that was conductedin cross-sectional study. The research will beconducted overa11-month withurinesamplingtodetermine levels ofMCP-1 in patients withSLE, andrenalbiopsy was performedtodetermine theclass oflupusnephritisaccording toWHO (1982) classification. Theresultsshowed nosignificant difference(p =0,247>α) between meanranklevels ofurinary uMCP-1of control and cases group. In theKruskal-Wallis test demonstrated the comparison of meanrankurineMCP-1levels among 3 groups  are nosignificant difference(p =0,197>α). It can be concluded that the levels of urinary MCP1 was not associated with incidence and histopathological classification of lupus nephritis.

Keyword: Lupus nephritis, uMCP-1, Histopathology class

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